Scope: soft-tissue infection without evidence of osteomyelitis. Probe-to-bone or exposed bone suggests osteomyelitis — treat as osteomyelitis (different workup and a longer course).
Broad Spectrum withOUT Gram Negative/AnaerobicStreptococci & MSSA & MRSA
ClindamycinCheck local antibiogram for MRSA resistance
300 to 450 mg PO q8h
Clindamycin AND Ciprofloxacin
Clindamycin300 to 450 mg PO q8h
Ciprofloxacin500 to 750 mg PO q12h
Other regimens for this scenario don't include Clindamycin — see the full page for the complete algorithm.