High Risk — MonotherapyHigh Risk: age ≥ 65, antibiotic use in last 90 days, alcoholism, smoking, or comorbidities (asplenia, heart / liver / lung / renal disease, diabetes, malignancy, etc.).
300 mg PO day 1–2, then 300 mg PO q24h7–14 days
Other regimens for this scenario don't include Omadacycline — see the full page for the complete algorithm.