EXPLODING BACTERIA
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SIRS Criteria
Temp >38°C (100.4°F) or <36°C (96.8°F)
HR >90 beats/min
RR >20 breaths/min or PaCO₂ <32 mmHg
WBC >12k or <4k or >10% bands
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macrolides
Unverified
Clarithromycin
Generic, Biaxin®
?
Pregnancy
?
Breastfeeding
?
Warfarin
Adult
Pediatric
Community-Acquired Pneumonia
1 scenario
Open the full CAP page →
Drug Safety
Monotherapy for Typical or Atypical Pneumonia
Clarithromycin
500 mg PO q12h
7 days
Combo Tx for Typical and/or Atypical Pneumonia
Amoxicillin + Atypical
Amoxicillin
○
Pick one
required
+
Atypical
○
Pick one
required
Select
Amoxicillin
✓
✓
!
Drug Info
1 g PO q8h
Liquid
125 mg/5 mL (25 mg/mL)
250 mg/5 mL (50 mg/mL)
400 mg/5 mL (80 mg/mL)
Tablets
500 mg
875 mg
Capsules
250 mg
500 mg
Brands
Generic, Amoxil®
View full Amoxicillin page →
+
AND Choose ONE Atypical
Azithromycin
?
?
?
Drug Info
500 mg PO day 1, then 250 mg PO q24h days 2–5
5 days
Tablets
250 mg
500 mg
600 mg
Suspension
100 mg/5 mL
200 mg/5 mL
1 g single-dose packet
IV
500 mg vial
Brands
Generic, Zithromax®, Z-Pak®
View full Azithromycin page →
Clarithromycin
?
?
?
Drug Info
500 mg PO q12h
7 days
Tablets
250 mg
500 mg
ER tablets
500 mg
Suspension
125 mg/5 mL
250 mg/5 mL
Brands
Generic, Biaxin®
View full Clarithromycin page →
Doxycycline
?
?
?
Drug Info
100 mg PO q12h
Capsules
50 mg
100 mg
Tablets
20 mg
50 mg
75 mg
100 mg
150 mg
Suspension / syrup
25 mg/5 mL
50 mg/5 mL
IV
100 mg vial
Brands
Generic, Vibramycin®, Doryx®
View full Doxycycline page →
High Risk — Combo Tx
β-Lactam + Atypical
High Risk: age ≥ 65, antibiotic use in last 90 days, alcoholism, smoking, or comorbidities (asplenia, heart / liver / lung / renal disease, diabetes, malignancy, etc.).
β-Lactam
○
Pick one
required
+
Atypical
○
Pick one
required
Choose ONE β-Lactam
Amoxicillin-Clavulanate
?
?
?
Drug Info
875/125 mg PO q12h
Tablets
500 / 125 mg
875 / 125 mg
ER tablets
1000 / 62.5 mg
Suspension
200 / 28.5 mg per 5 mL
400 / 57 mg per 5 mL
600 / 42.9 mg per 5 mL (ES-600)
Brands
Generic, Augmentin®
View full Amoxicillin-Clavulanate page →
Cefpodoxime₃
?
?
?
Drug Info
200 mg PO q12h
Tablets
100 mg
200 mg
Suspension
50 mg/5 mL
100 mg/5 mL
Brands
Generic, Vantin®
View full Cefpodoxime page →
Cefuroxime₂
?
?
?
Drug Info
500 mg PO q12h
Tablets
250 mg
500 mg
Suspension
125 mg/5 mL
250 mg/5 mL
IV / IM
750 mg
1.5 g vials
Brands
Generic, Ceftin® (oral), Zinacef® (injectable)
View full Cefuroxime page →
+
AND Choose ONE Atypical
Azithromycin
?
?
?
Drug Info
500 mg PO day 1, then 250 mg PO q24h days 2–5
5 days
Tablets
250 mg
500 mg
600 mg
Suspension
100 mg/5 mL
200 mg/5 mL
1 g single-dose packet
IV
500 mg vial
Brands
Generic, Zithromax®, Z-Pak®
View full Azithromycin page →
Clarithromycin
?
?
?
Drug Info
500 mg PO q12h
7 days
Tablets
250 mg
500 mg
ER tablets
500 mg
Suspension
125 mg/5 mL
250 mg/5 mL
Brands
Generic, Biaxin®
View full Clarithromycin page →
Doxycycline
?
?
?
Drug Info
100 mg PO q12h
Capsules
50 mg
100 mg
Tablets
20 mg
50 mg
75 mg
100 mg
150 mg
Suspension / syrup
25 mg/5 mL
50 mg/5 mL
IV
100 mg vial
Brands
Generic, Vibramycin®, Doryx®
View full Doxycycline page →
Other regimens for this scenario don't include Clarithromycin — see the full page for the complete algorithm.
No pediatric regimens reference Clarithromycin yet.
Drug Info
Tablets
250 mg
500 mg
ER tablets
500 mg
Suspension
125 mg/5 mL
250 mg/5 mL
Brands
Generic, Biaxin®
Safety
?
Pregnancy
Not yet reviewed.
?
Breastfeeding
Not yet reviewed.
?
Warfarin
Not yet reviewed.