EXPLODING BACTERIAMed Decision Speed Tools
sulfonamidesUnverified

Trimethoprim-Sulfamethoxazole

Generic, Bactrim®, Septra®
?Pregnancy?Breastfeeding?Warfarin
Open the full DFI page →
Scope: soft-tissue infection without evidence of osteomyelitis. Probe-to-bone or exposed bone suggests osteomyelitis — treat as osteomyelitis (different workup and a longer course).
MRSA Risk FactorsMSSA & MRSA (with variable streptococci coverage)
TMP-SMX
1 to 2 DS tablets (160/800 mg) PO q12h
ClindamycinCheck local antibiogram for MRSA resistance
???
300 to 450 mg PO q8h
Capsules
75 mg150 mg300 mg
Oral solution
75 mg/5 mL
IV / IM
150 mg/mL
BrandsGeneric, Cleocin®
View full Clindamycin page →
Doxycycline AND Cephalexin₁
Doxycycline100 mg PO q12h
Cephalexin₁500 mg PO q6h
Doxycycline AND Dicloxacillin
Doxycycline100 mg PO q12h
Dicloxacillin500 mg PO q6h
Linezolid
???
PO and IV have the same bioavailability.
600 mg PO q12h
Tablets
600 mg
Liquid
100 mg/5 mL
IV
600 mg/300 mL
BrandsGeneric, Zyvox®
View full Linezolid page →
TMP-SMX and Cephalexin₁
TMP-SMX1 to 2 DS tablets (160/800 mg) PO q12h
Cephalexin₁500 mg PO q6h
TMP-SMX and Dicloxacillin
TMP-SMX1 to 2 DS tablets (160/800 mg) PO q12h
Dicloxacillin500 mg PO q6h
Doxycycline AND Amoxicillin-Clavulanate
Doxycycline100 mg PO q12h
Amoxicillin-Clavulanate875/125 mg PO q12h
Doxycycline AND Moxifloxacin
Doxycycline100 mg PO q12h
Moxifloxacin400 mg PO q24h
TMP-SMX and Amoxicillin-Clavulanate
TMP-SMX1 to 2 DS tablets (160/800 mg) PO q12h
Amoxicillin-Clavulanate875/125 mg PO q12h
TMP-SMX and Moxifloxacin
TMP-SMX1 to 2 DS tablets (160/800 mg) PO q12h
Moxifloxacin400 mg PO q24h
Other regimens for this scenario don't include Trimethoprim-Sulfamethoxazole — see the full page for the complete algorithm.

Drug Info

Tablets
400/80 mg (single strength)800/160 mg (DS)
Suspension
200/40 mg per 5 mL
IV
80/16 mg per mL
BrandsGeneric, Bactrim®, Septra®

Safety

?PregnancyNot yet reviewed.
?BreastfeedingNot yet reviewed.
?WarfarinNot yet reviewed.